The uterus is the reproductive organ that contains and nourishes the embryo and fetus from the time a fertilized egg implants to the time the fetus is born. The ovary is a gland in the female that produces the ovum, or reproductive cell, and two hormones (estrogen and progesterone). There are two ovaries, one at either side of the pelvis. Oophorohysterectomy is the surgical removal of the uterus and the ovaries.

Cancer of the uterus, cervix and ovaries are the major causes of removal of the uterus and ovaries. Other causes may be endometriosis; uterine fibroids; chronic pelvic pain; dysfunctional uterine bleeding (DUB); hyperplasia, hydatidiform mole in pregnancy; ovarian cysts; or benign tumors.

Signs and symptoms may vary depending on the specific disease. These may include: abnormal menstrual periods; pain in the lower abdomen or back; abnormal bleeding patterns; fever; cramps; painful intercourse; infertility; or abnormal vaginal discharge, which may be pink, watery, or excessively malodorous. There may be a pelvic mass, enlarged uterus, or altered urinary and bowel function. In pregnancy, the uterus may enlarge too quickly. There may also be excess facial hair, abdominal bloating or swelling, or abnormal hormone levels.

History and physical examinations, laboratory tests, x-ray, computed tomography (CT) scan, magnetic resonance imaging (MRI), pelvic ultrasonography, and laparotomy for cancer staging of the disease may be done.

Depending on the disease, surgical removal of the organs may vary from removal of the uterus and ovaries to radical removal of these organs including the fallopian tubes and lymph nodes. Radiation or chemotherapy may be used in addition to surgery for cancerous causes. Hormone therapies may also be used after surgery.

In the event of cancer, the outcome may depend on the stage and amount of residual disease, as well as the patient's genetic and biologic factors. There is potential for recurrence or metastasis postoperatively. Development of osteoporosis may occur. Long-term hormone therapy may be indicated. Counseling, psychotherapy, and support groups may be indicated to assist the patient in dealing with the diagnosis.

• Natural menopause, primary amenorrhea, and pregnancy and childbirth are not disabilities for rating purposes. Chronic residuals of medical or surgical complications of pregnancy may be disabilities for rating purposes.
• When evaluating any claim involving loss or loss of use of one or more creative organs or anatomical loss of one or both breasts, refer to 38 CFR 3.350 to determine whether the Veteran may be entitled to special monthly compensation. Footnotes in the schedule indicate conditions which potentially establish entitlement to special monthly compensation; however, almost any condition in 38 CFR 4.116 might, under certain circumstances, establish entitlement to special monthly compensation.
• May be entitled to special monthly compensation where the veteran has a single service-connected disability rated as 100% with additional service-connected disability or disabilities independently ratable at 60% or more, which are separate and distinct from the 100% service-connected disability and involves different anatomical segments or bodily systems. See  38 CFR 3.350(i)(1) – Special Monthly Compensation (SMC).